Tesco is seeking planning permission to construct a distribution development on part of the former Esso Research Centre in Milton Hill, Vale of White Horse, near Didcot.
Logistics Manager revealed that Tesco was looking for a site in the area last month (LM 10th April).
Located on the edge of Milton Hill Village, the application site extends to approximately 3.12 ha and is bounded by the A313 to the east and Featherbed Lane to the west.
Previously a research and development facility operated by Esso, all buildings on site have now been demolished and the site itself remediated and cleared.
The proposal is for a home delivery distribution centre, to include a specialised and automated B8 warehouse that processes internet shopping orders.
The dot-com centre would operate 24/7 and employ approximately 750 staff over three shifts, the equivalent to 500 full timers.
If construction goes ahead, it will have a floor area of 11,458 sq m and around 481 parking spaces, 260 for staff and 221 for vans.
The application is part of a wider master plan for the site, which could see a second phase of development confirmed at a later date, for an office led development to the east of the current proposed application.